Immunotherapy of a murine B cell tumor with antibodies and F(ab')2 fragments against idiotypic determinants of its cell surface IgM

Y. Perek, E. Hurwitz, D. Burowski, J. Haimovich

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Anti-idiotype antibodies against the IgM of the 38C-13 murine B lymphocyte cell line and F(ab')2 fragments derived from them were checked for their therapeutic effect against the killing of mice by 38C-13 cells. Both intact molecules and the F(ab')2 fragments were effective in delaying or preventing the killing of mice by 38C-13 tumors when used in large amounts and by the appropriate routes.

Original languageEnglish
Pages (from-to)1600-1603
Number of pages4
JournalJournal of Immunology
Volume131
Issue number3
StatePublished - 1983

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