Immunotherapy for Alzheimer's disease: attacking amyloid-β from the inside

Michal Arbel*, Beka Solomon

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


Although extracellular Aβ plaques are a hallmark of Alzheimer's disease, it remains to be determined whether extracellular or intracellular Aβ accumulation initiates the disease process. A recent paper from Gunnar Gouras' group showed that Aβ antibodies lead to reduced intracellular Aβ levels in neurons via antibody internalization after binding to the Aβ domain of amyloid precursor protein (APP) at the plasma membrane. This work suggests novel avenues for the immunotherapy of Alzheimer's disease.

Original languageEnglish
Pages (from-to)511-513
Number of pages3
JournalTrends in Immunology
Issue number12
StatePublished - Dec 2007


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