TY - JOUR
T1 - Immunotherapy for Alzheimer's disease
T2 - attacking amyloid-β from the inside
AU - Arbel, Michal
AU - Solomon, Beka
PY - 2007/12
Y1 - 2007/12
N2 - Although extracellular Aβ plaques are a hallmark of Alzheimer's disease, it remains to be determined whether extracellular or intracellular Aβ accumulation initiates the disease process. A recent paper from Gunnar Gouras' group showed that Aβ antibodies lead to reduced intracellular Aβ levels in neurons via antibody internalization after binding to the Aβ domain of amyloid precursor protein (APP) at the plasma membrane. This work suggests novel avenues for the immunotherapy of Alzheimer's disease.
AB - Although extracellular Aβ plaques are a hallmark of Alzheimer's disease, it remains to be determined whether extracellular or intracellular Aβ accumulation initiates the disease process. A recent paper from Gunnar Gouras' group showed that Aβ antibodies lead to reduced intracellular Aβ levels in neurons via antibody internalization after binding to the Aβ domain of amyloid precursor protein (APP) at the plasma membrane. This work suggests novel avenues for the immunotherapy of Alzheimer's disease.
UR - http://www.scopus.com/inward/record.url?scp=36048998867&partnerID=8YFLogxK
U2 - 10.1016/j.it.2007.09.005
DO - 10.1016/j.it.2007.09.005
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C2 - 17981084
AN - SCOPUS:36048998867
SN - 1471-4906
VL - 28
SP - 511
EP - 513
JO - Trends in Immunology
JF - Trends in Immunology
IS - 12
ER -