Immunosuppressive drugs after simultaneous pancreas-kidney transplantation

J. Malaise*, D. R.J. Kuypers, K. Claes, P. Evenepoel, B. Maes, W. Coosemans, J. Pirenne, Y. Vanrenterghem, D. Van Ophem, J. P. Squifflet, W. O. Bechstein, A. Kahl, J. Langrehr, I. Uhl, A. Engelking, P. Neuhaus, M. Stangl, W. D. Illner, A. Tarabichi, H. SchneebergerArbogast, W. Land, C. Dieterle, R. Landgraf, P. Boucek, M. Adamec, T. Havrdova, R. Koznarova, F. Saudek, W. Steurer, A. Königsrainer, R. Margreiter, Mark, M. J. Ricart, L. Fernandez-Cruz, R. Nakache, R. Caldara, A. Secchi, D. Kuypers, Th Messiaen, J. Sandberg, G. Tyden, M. Mourad, T. Berney, P. Majno, C. Toso, L. Bühler, G. Mentha, N. De Carpentry, S. Demuylder-Mischler, P. Morel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction. We report the early and late secondary effects of tacrolimus or cyclosporine-microemulsion (ME), in combination with mycophenolate mofetil (MMF), and rATG. Patients and methods. One hundred three patients were randomly assigned to tacrolimus (initial oral dose 0.2 mg/kg) and 102 to cyclosporine-ME (initial daily oral dose 7 mg/kg). All patients received 4 days of concomitant rATG induction therapy [ATG-Fresenius Biotech GmbH (ATG-F) daily dose of 4mg/kg or Thymoglobulin-Genzyme/Sangstat (Thymo-S) 1.25 mg/kg], MMF (2 to 3 g per day), and short-term corticosteroids. Results. Thymo-S was associated with a transiently lower white cell count in the first 3 months compared with ATG-F, while ATG-F caused a lower albeit transient early nadir in platelet count. Both polyclonal preparations were well tolerated; they did not differ with respect to clinically relevant side effects such as infections and malignancies. Higher cyclosporine-ME trough levels were associated with pancreas graft thrombosis. Study withdrawal was more frequent among patients on cyclosporine-ME therapy, because of toxicities, graft loss, and lack of efficacy, the last being the cause of subsequent switch to tacrolimus. Tacrolimus-treated patients were mainly withdrawn from the study due to MMF discontinuation. Conclusion. Short-term induction therapy in combined kidney-pancreas transplantation is effective and well tolerated. Tacrolimus causes fewer pancreas graft losses and fewer drug discontinuations due to side effects. When MMF is combined with tacrolimus, dose reductions and discontinuations are common.

Original languageEnglish
Pages (from-to)2840-2842
Number of pages3
JournalTransplantation Proceedings
Issue number6
StatePublished - 2005


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