Immunosuppressant material in human seminal fluid inhibition of blast transformation and of NK activity by seminal fluid patients of a male infertility clinic

Zvi H. Marcus, Bruno Lunenfeld, Ruth Weissenberg, Lawrence M. Lewin

Research output: Contribution to journalArticlepeer-review

Abstract

Human seminal plasma from normal or patients with abnormal parameters of the ejaculates contains an inhibitory material that expresses potent in vitro inhibitory activity on PHA-M-induced blast transformation and NK acitivity. Using the test of inhibition of NK activity, the semen samples from individuals with higher concentrations of fructose had higher inhibitory activity. The results described herein suggest that inhibitory activity for blast transformation may be present in the prostatic fluid while the NK inhibition aspects are correlated with the vesicle-marker (fructose). Inhibition of the immune responses by human seminal plasma of the effector functions indicates the interesting implication that soluble factors may indirectly protect against or promote human autoimmune infertility disease.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume23
Issue number1
DOIs
StatePublished - 1987

Keywords

  • Human seminal plasma
  • Immunosuppression
  • Inhibition of NK activity
  • Inhibition of blast transformation

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