Immunoreactive and bioactive somatostatin-like material is present in tobacco (Nicotiana tabacum)

Haim Werner; Mati Fridkin; Dvora Aviv; Yitzhak Koch

doi:10.1016/0196-9781(85)90304-3

Immunoreactive and bioactive somatostatin-like material is present in tobacco (Nicotiana tabacum)

Haim Werner^*, Mati Fridkin, Dvora Aviv, Yitzhak Koch

^*Corresponding author for this work

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Immunoreactive and biologically active somatostatin-like material is present in extracts of tobacco plants (Nicotiana tabacum). Comparative chromatographic and immunological characterization of this peptide along with synthetic (hypothalamic-like) somatostatin-14 and -28, indicates that both molecular forms are present in the plant. Tobacco-somatostatin inhibits the prostaglandin E₂-induced release of growth hormone from cultured anterior pituitary cells. This finding raises questions concerning the evolutionary mechanisms responsible for the presence of this neuropeptide in plants, and the physiological significance of this phenomena.

Original language	English
Pages (from-to)	797-802
Number of pages	6
Journal	Peptides
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/0196-9781(85)90304-3
State	Published - 1985
Externally published	Yes

Keywords

Evolution of neuropeptides
Immunoreactive and bioactive somatostatin
Tobacco plants

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10.1016/0196-9781(85)90304-3

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abstract = "Immunoreactive and biologically active somatostatin-like material is present in extracts of tobacco plants (Nicotiana tabacum). Comparative chromatographic and immunological characterization of this peptide along with synthetic (hypothalamic-like) somatostatin-14 and -28, indicates that both molecular forms are present in the plant. Tobacco-somatostatin inhibits the prostaglandin E2-induced release of growth hormone from cultured anterior pituitary cells. This finding raises questions concerning the evolutionary mechanisms responsible for the presence of this neuropeptide in plants, and the physiological significance of this phenomena.",

keywords = "Evolution of neuropeptides, Immunoreactive and bioactive somatostatin, Tobacco plants",

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AU - Fridkin, Mati

AU - Aviv, Dvora

AU - Koch, Yitzhak

PY - 1985

Y1 - 1985

N2 - Immunoreactive and biologically active somatostatin-like material is present in extracts of tobacco plants (Nicotiana tabacum). Comparative chromatographic and immunological characterization of this peptide along with synthetic (hypothalamic-like) somatostatin-14 and -28, indicates that both molecular forms are present in the plant. Tobacco-somatostatin inhibits the prostaglandin E2-induced release of growth hormone from cultured anterior pituitary cells. This finding raises questions concerning the evolutionary mechanisms responsible for the presence of this neuropeptide in plants, and the physiological significance of this phenomena.

AB - Immunoreactive and biologically active somatostatin-like material is present in extracts of tobacco plants (Nicotiana tabacum). Comparative chromatographic and immunological characterization of this peptide along with synthetic (hypothalamic-like) somatostatin-14 and -28, indicates that both molecular forms are present in the plant. Tobacco-somatostatin inhibits the prostaglandin E2-induced release of growth hormone from cultured anterior pituitary cells. This finding raises questions concerning the evolutionary mechanisms responsible for the presence of this neuropeptide in plants, and the physiological significance of this phenomena.

KW - Evolution of neuropeptides

KW - Immunoreactive and bioactive somatostatin

KW - Tobacco plants

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Immunoreactive and bioactive somatostatin-like material is present in tobacco (Nicotiana tabacum)

Abstract

Keywords

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