Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells

Hanna Bessler; Ronit Weizman; Moshe Gavish; Ida Notti; Meir Djaldetti

doi:10.1016/0165-5728(92)90086-Z

Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells

Hanna Bessler, Ronit Weizman, Moshe Gavish, Ida Notti, Meir Djaldetti^*

^*Corresponding author for this work

Clinical Departments

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52 Scopus citations

Abstract

Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.

Original language	English
Pages (from-to)	19-25
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	38
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-5728(92)90086-Z
State	Published - May 1992

Keywords

Interleukin-2
Interleukin-3-like activity
Mitogen-induced proliferation
Peripheral benzodiazepine receptor

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10.1016/0165-5728(92)90086-Z

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title = "Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells",

abstract = "Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.",

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author = "Hanna Bessler and Ronit Weizman and Moshe Gavish and Ida Notti and Meir Djaldetti",

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AU - Bessler, Hanna

AU - Weizman, Ronit

AU - Gavish, Moshe

AU - Notti, Ida

AU - Djaldetti, Meir

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AB - Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.

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Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells

Abstract

Keywords

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