Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells

Hanna Bessler, Ronit Weizman, Moshe Gavish, Ida Notti, Meir Djaldetti

Research output: Contribution to journalArticlepeer-review

Abstract

Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalJournal of Neuroimmunology
Volume38
Issue number1-2
DOIs
StatePublished - May 1992

Keywords

  • Interleukin-2
  • Interleukin-3-like activity
  • Mitogen-induced proliferation
  • Peripheral benzodiazepine receptor

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