Immunomodulation in human and experimental arthritis: Including vitamin D, helminths and heat-shock proteins

Llw Ishikawa, Y. Shoenfeld, A. Sartori

Research output: Contribution to journalArticlepeer-review

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is mainly directed to the joints, affecting the synovial membrane, the cartilage and also the bone. This disease affects 1% to 2% of the world population and is associated with significant morbidity and increased mortality. RA experimental models have allowed a great deal of information to be translated to the corresponding human disease. This review summarizes some of the most relevant findings targeting immunomodulation in arthritis. Some general guidelines to choose an adequate experimental model and also our experience with arthritis are supplied.

Original languageEnglish
Pages (from-to)577-587
Number of pages11
JournalLupus
Volume23
Issue number6
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • Rheumatoid arthritis
  • dendritic cells
  • heat-shock proteins
  • helminths
  • regulatory T cells
  • vitamin D

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