Immunology: The effect of serum follicular phase luteinizing hormone concentrations in habitual abortion: Correlation with results of paternal leukocyte immunization

H. J.A. Carp*, Y. Hass, M. Dolicky, M. Goldenberg, S. Mashiach, J. Rabinovici

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A prospective study was carried out on 153 couples with recurrent abortions who desired pregnancy. The object was to determine the incidence of raised luteinizing hormone (LH) levels; to compare the outcome of further pregnancies in habitually aborting women with and without raised circulating LH concentrations; and to assess whether the efficacy of paternal leukocyte immunization is affected in the presence of raised LH concentrations. Of the 153 women with recurrent abortions (>3) included in this study, 56 (36.6%) had follicular phase serum LH concentrations >10 mIU/ml. Of the 103 pregnancies that were followed prospectively, 65 (63.1%) resulted in a birth of a live infant. There was no significant relationship between the pregnancy outcome and LH concentrations. Women who underwent immunization with paternal leukocytes had significantly more live births (75.8%) than those who were not immunized (43.6%). However, the live birth rate was lower after paternal leukocyte immunization in the presence of raised LH concentrations or a raised LH/follicle stimulating hormone (FSH) ratio.

Original languageEnglish
Pages (from-to)1702-1705
Number of pages4
JournalHuman Reproduction
Volume10
Issue number7
DOIs
StatePublished - Jul 1995

Keywords

  • Habitual abortion
  • LH concentrations
  • Paternal leukocyte immunization

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