TY - JOUR
T1 - Immunology, autoimmunity, and autoantibodies in parkinson's disease
AU - Benkler, Michal
AU - Agmon-Levin, Nancy
AU - Hassin-Baer, Sharon
AU - Cohen, Oren S.
AU - Ortega-Hernandez, Oscar Danilo
AU - Levy, Amalia
AU - Moscavitch, Samuel Datum
AU - Szyper-Kravitz, Martine
AU - Damianovich, Maya
AU - Blank, Miri
AU - Chapman, Joab
AU - Shoenfeld, Yehuda
PY - 2012/4
Y1 - 2012/4
N2 - Recent revelations of immune alterations in Parkinson's disease have led to the convergence that an autoimmune mechanism may play a role in the etiopathogenesis of this neurodegenerative disease. In the current study, 77 Parkinson's disease patients and 77 matched healthy controls were analyzed for the presence of seven autoantibodies previously found to be associated with central nervous system manifestations namely: antineuronal-cells, anti-brain lysate, anti-dsDNA, anti-phosphatidylserine, anti-cardiolipin, anti-serotonin, and anti-melanocytes antibodies. Patients underwent systematic assessments of demographics, clinical, and biochemical manifestations. Three autoantibodies were found to be more prevalent among Parkinson's disease patients (antineuronal cells10.3% vs. 1.3%, p=0.017; antibrain lysate 9.1% vs. 1.3%, p=0.032; anti-dsDNA 10.3% vs. 2.6%, p=0.049). Clinical manifestations of Parkinson's disease, particularly dyskinesia and depression, were found to be associated with the presence of these autoantibodies.
AB - Recent revelations of immune alterations in Parkinson's disease have led to the convergence that an autoimmune mechanism may play a role in the etiopathogenesis of this neurodegenerative disease. In the current study, 77 Parkinson's disease patients and 77 matched healthy controls were analyzed for the presence of seven autoantibodies previously found to be associated with central nervous system manifestations namely: antineuronal-cells, anti-brain lysate, anti-dsDNA, anti-phosphatidylserine, anti-cardiolipin, anti-serotonin, and anti-melanocytes antibodies. Patients underwent systematic assessments of demographics, clinical, and biochemical manifestations. Three autoantibodies were found to be more prevalent among Parkinson's disease patients (antineuronal cells10.3% vs. 1.3%, p=0.017; antibrain lysate 9.1% vs. 1.3%, p=0.032; anti-dsDNA 10.3% vs. 2.6%, p=0.049). Clinical manifestations of Parkinson's disease, particularly dyskinesia and depression, were found to be associated with the presence of these autoantibodies.
KW - Autoantibodies
KW - Autoimmune
KW - Depression
KW - Dyskinesia
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=84862891901&partnerID=8YFLogxK
U2 - 10.1007/s12016-010-8242-y
DO - 10.1007/s12016-010-8242-y
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C2 - 21234712
AN - SCOPUS:84862891901
SN - 1080-0549
VL - 42
SP - 164
EP - 171
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
IS - 2
ER -