TY - JOUR
T1 - Immunological options for the treatment of tuberculosis
T2 - Evaluation of novel therapeutic approaches
AU - Achkar, Jacqueline M.
AU - Casadevall, Arturo
AU - Glatman-Freedman, Aharona
N1 - Funding Information:
Achkar, Casadevall and Glatman-Freedman are Center for AIDS Research (CFAR) investigators at the Albert Einstein College of Medicine. Achkar is supported in part by a CFAR pilot grant and NIH grant AI067665. Casadevall is supported in part by the Northeast Biodefense Center U54-AI057158-Lipkin.
PY - 2007/6
Y1 - 2007/6
N2 - The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view of the epidemiological and clinical challenges, and explore the experience with immune-based therapies for the treatment of active tuberculosis. These immune-based therapies are discussed here with the aim of assessing their potential use as adjuncts to chemotherapy.
AB - The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view of the epidemiological and clinical challenges, and explore the experience with immune-based therapies for the treatment of active tuberculosis. These immune-based therapies are discussed here with the aim of assessing their potential use as adjuncts to chemotherapy.
KW - Antibodies
KW - Cytokines
KW - Immunotherapy
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=34447286457&partnerID=8YFLogxK
U2 - 10.1586/14787210.5.3.461
DO - 10.1586/14787210.5.3.461
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C2 - 17547510
AN - SCOPUS:34447286457
SN - 1478-7210
VL - 5
SP - 461
EP - 474
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
IS - 3
ER -
