TY - JOUR
T1 - Immunological evaluation of asymptomatic carriers of hepatitis B virus
AU - Levo, Y.
AU - Shouval, D.
AU - Tur-Kaspa, R.
AU - Wollner, S.
AU - Penchas, S.
AU - Zlotnick, A.
AU - Eliakim, M.
PY - 1981
Y1 - 1981
N2 - The immune system of 69 asymptomatic HBsAg carriers with normal liver function tests was evaluated. B cell function, as documented by serum immunoglobulin levels, number of mouse rosette-forming lymphocytes and lymphocyte reactivity to staphylococcal protein A, was intact. On the other hand, T cell function was markedly impaired. This was manifested by a significant decrease in E rosette-forming lymphocytes, and increase in stable rosette-forming cells and decreased reactivity to phytohaemagglutinin and concanavalin A. These data rule out the possibility that the immunological aberrations associated with hepatitis B infection are secondary to liver injury. The abnormal immune state either precedes the viral infection, thus predisposing to the acquisition of a carrier state or, alternatively, is a direct result of the infection.
AB - The immune system of 69 asymptomatic HBsAg carriers with normal liver function tests was evaluated. B cell function, as documented by serum immunoglobulin levels, number of mouse rosette-forming lymphocytes and lymphocyte reactivity to staphylococcal protein A, was intact. On the other hand, T cell function was markedly impaired. This was manifested by a significant decrease in E rosette-forming lymphocytes, and increase in stable rosette-forming cells and decreased reactivity to phytohaemagglutinin and concanavalin A. These data rule out the possibility that the immunological aberrations associated with hepatitis B infection are secondary to liver injury. The abnormal immune state either precedes the viral infection, thus predisposing to the acquisition of a carrier state or, alternatively, is a direct result of the infection.
UR - http://www.scopus.com/inward/record.url?scp=0019420358&partnerID=8YFLogxK
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AN - SCOPUS:0019420358
SN - 0009-9104
VL - 44
SP - 63
EP - 67
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 1
ER -