Immunologic Alterations Induced by Phenytoin

Yoram Levo*

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review


To the Editor: In the February 18 issue, Dosch and his colleagues1 suggest that at least some of the immunologic abnormalities associated with phenytoin (diphenylhydantoin) are due to enhancement of suppressor T cells. Specifically, in their patient they noted a transient antibody deficiency associated with increased suppressor-T-cell activity, as measured by the plaque-forming-cell assay. In 1975, we performed a series of experiments in mice to test the influence of hydantoin on some measures of the immune response and to evaluate its capacity to modify carcinogenesis.2 We have used the model of urethane-induced lung adenomas in SWR mice. In this model.

Original languageEnglish
Pages (from-to)315-316
Number of pages2
JournalNew England Journal of Medicine
Issue number5
StatePublished - 29 Jul 1982
Externally publishedYes


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