TY - JOUR
T1 - Immunologic alterations in MRL/lpr mice after chronic dimethyl sulfoxide administration
AU - Wysenbeek, Arjeh J.
AU - Lourie, Sylvie
AU - Weinberger, Abraham
AU - Schoenfeld, Nili
AU - Pick, Albert I.
AU - Pecht, Marit
PY - 1987
Y1 - 1987
N2 - Dimethy sulfoxide (DMSO) in 1 and 2% concentration was added to the drinking water of 30 - 100 day MRL/lpr mice. In comparison to control mice, the DMSO treated mice had a 78% increase in their response to exogenous IL-2 and a 64% increase in production of IL-2. Con A stimulated cells had a net help effect in the untreated mice, which was suppressed from 82 - 26% after DMSO treatment. There was no marked change in Thy 1.2, Lyt 1 and Lyt 2 percentages after treatment. The anti-DNA decreased from 29 ± 17.0% to 13.2 ± 7.8% after DMSO treatment. We conclude that chronic DMSO administration to MRL/lpr mice can induce immunologic alterations with possible clinical implications.
AB - Dimethy sulfoxide (DMSO) in 1 and 2% concentration was added to the drinking water of 30 - 100 day MRL/lpr mice. In comparison to control mice, the DMSO treated mice had a 78% increase in their response to exogenous IL-2 and a 64% increase in production of IL-2. Con A stimulated cells had a net help effect in the untreated mice, which was suppressed from 82 - 26% after DMSO treatment. There was no marked change in Thy 1.2, Lyt 1 and Lyt 2 percentages after treatment. The anti-DNA decreased from 29 ± 17.0% to 13.2 ± 7.8% after DMSO treatment. We conclude that chronic DMSO administration to MRL/lpr mice can induce immunologic alterations with possible clinical implications.
UR - http://www.scopus.com/inward/record.url?scp=0023521545&partnerID=8YFLogxK
U2 - 10.1016/0192-0561(87)90072-5
DO - 10.1016/0192-0561(87)90072-5
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0023521545
SN - 0192-0561
VL - 9
SP - 769
EP - 773
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
IS - 7
ER -