Immunologic Abnormalities Associated With Primary Anetoderma

Emmilia Hodak*, Orna Shamai-Lubovitz, Michael David, Bilha Hazaz, Varda Katzenelson-Weissman, Meir Lahav, Miriam Sandbank

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background and Design.— Primary anetoderma is a rare cutaneous elastolytic disorder, the etiopathogenesis of which has not yet been established. Six patients with primary anetoderma were studied in an attempt to assess the role of the immunologic system in the elastolytic process. The investigation included the medical history, physical examination, routine blood tests, specific tests for collagen diseases, prothrombin time, activated partial thromboplastin time, thyroxine, indirect immunofluorescence test, and skin biopsies for histopathologic study and direct immunofluorescence. Results.— Two of the patients presented with autoimmune disorders: the first had Graves' disease, lupus anticoagulant, and autoimmune hemolysis, and the second had systemic scleroderma. There were positive direct immunofluorescence findings in most of the patients. Furthermore, all of them were found to have serologic immunologic abnormalities, of which the most common was a positive antinuclear factor. Conclusions.— These findings indicate that there is an immunologic involvement in primary anetoderma. (Arch Dermatol. 1992;128:799-803).

Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalArchives of Dermatology
Issue number6
StatePublished - Jun 1992


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