Immunohistochemical Study of Pancreatic Neuroendocrine Tumor in Panthera tigris tigris

A. Nyska*, J. Goldstein, G. Eshkar, B. Klein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The histological and immunohistochemical characteristics of a case of pancreatic neuroendocrine tumor are described in a 14-yr-old female Bengal tiger (Panthera tigris tigris) housed at the New Biblical Zoo of Jerusalem, Jerusalem, Israel, 1994. The neoplastic cells were immunohistochemically negative for insulin and glucagon, slightly positive for neuron-specific enolase, moderately positive for serotonin and somatostatin, and markedly positive for chromogranine A and gastrin. This is the first documentation of a pancreatic neuroendocrine tumor in the tiger.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalJournal of Wildlife Diseases
Issue number3
StatePublished - Jul 1996
Externally publishedYes


  • Immunohistochemistry
  • Neuroendocrine tumor
  • Pancreas
  • Panthera tigris tigris


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