@article{32e33b5887ff43ba82922796275ecdbd,
title = "Immunoglobulin free light chains in saliva: a potential marker for disease activity in multiple sclerosis",
abstract = "A new procedure was developed and applied to study immunoglobulin free light chains (FLC) in saliva of healthy subjects and patients with multiple sclerosis (MS). The procedure was based on a Western blot analysis for detection and semiquantitative evaluation of monomeric and dimeric FLCs. The FLC indices accounting for the total FLC levels and for the monomer/dimer ratios of κ and λ FLC were calculated, and the cut-off values of the FLC indices were determined to distinguish healthy state from MS disease. The obtained FLC index values were statistically different in the saliva of three groups: active MS patients, MS patients in remission and healthy subjects groups. Our FLC monomer–dimer analysis allowed differentiation between healthy state and active MS with specificity of 100\% and a sensitivity of 88·5\%. The developed technique may serve as a new non-invasive complementary tool to evaluate the disease state by differentiating active MS from remission with sensitivity of 89\% and specificity of 80\%.",
keywords = "dimers, immunoglobulin free light chains, monomers, multiple sclerosis, saliva",
author = "B. Kaplan and S. Golderman and E. Ganelin-Cohen and A. Miniovitch and E. Korf and I. Ben-Zvi and A. Livneh and S. Flechter",
note = "Publisher Copyright: {\textcopyright} 2017 British Society for Immunology",
year = "2018",
month = apr,
doi = "10.1111/cei.13086",
language = "אנגלית",
volume = "192",
pages = "7--17",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Oxford University Press",
number = "1",
}