Immunoglobulin A in the epithelium of the respiratory tract and intrahepatic bile ducts of fetuses and newborns with pneumonia and sepsis

Herzl Ben-Hur, Pavel Gurevich, Monika Huszar, Nadja Ziv-Sokolovsky, Hagay Zion, Ilya Isaegson, Valentina Berman, Igor Zusman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The level of different immunoglobulins (IgA, IgG, IgM) in the tissues of 38 late fetuses and newborns was studied with peroxidase-labeled monoclonal antibodies. IgA+ and IgM+ lymphocytes were found in the spleen, lymph nodes and sometimes in the liver. IgG+ lymphocytes were not found. A high level of IgA+ material was found in the epithelium of the trachea, the epithelium and submucosal glands of the bronchi, but not the bronchioles, and in the epithelium of hepatic bile ducts and in their lumina. Such IgA is considered to be secretory - sIgA. Secretory IgA-containing epithelial cells appeared at 20 to 21 weeks of gestation; their number increased from 2.5 cells/10,000 μm2 in 23- to 26-week-old fetuses, to 8 cells/10,000 μm2 in 36- to 40-week-old fetuses. Secretory IgG and IgM were not detected. In fetuses with pneumonia or sepsis, the number of IgM+ and IgA+ lymphocytes increased significantly. IgM+ lymphocytes appeared not only in the spleen and lymph nodes, but also in the lungs. In such cases, the number of sIgA-containing epithelial cells in the trachea, bronchi and intrahepatic bile ducts decreased sometimes completely disappearing. The amount of IgA+ material in the lumina of these organs increased reflecting an intensification of sIgA secretion during infections. The presence of a marked amount of sIgA in fetuses from week 20 of gestation is considered to reflect the high importance of this immunoglobulin against normal contamination by microbes after birth, and to evidence the early maturation of the immune system.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalHuman Antibodies
Issue number3
StatePublished - 1997
Externally publishedYes


  • Fetuses
  • Full-term
  • Low birth weight
  • Newborns
  • Secretory IgA
  • Sepsis


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