Immunogenetics of juvenile chronic arthritis in Israel

C. Brautbar, M. Mukamel, M. Yaron, Y. Naparstek, S. H. Korman, A. Amar, I. Cohen, A. Ludomirsky, C. Lotan, J. Scharf

Research output: Contribution to journalArticlepeer-review


Typing for HLA-A,B.C and DR antigens was performed in 61 Israeli patients with juvenile chronic arthritis (JCA) and in 120 unrelated controls. No significant associations were apparent in the overall patient group. DR5 was significantly increased in the non-Ashkenazi patients with pauciarticular onset of disease. The only three DRw8 positive patients in the study had pauciarticular onset. DR5 and DRw8 were found in 9 of 10 patients with age of onset less than 3 years. Increased frequencies of Bw50 and Cw6 were observed in patients with systemic onset. Typing for properdin factor (Bf) and glyoxylase (GLO) was carried out in 45 and 50 of the patients, respectively. No associations with alleles of the complement Bf system or the HLA linked GLO system were evident. The confirmation in the ethnically distinct Israeli population of the previously described association of DR5 with pauciarticular JCA suggests that this gene may be closely related to the disease susceptibility gene.

Original languageEnglish
Pages (from-to)1072-1075
Number of pages4
JournalJournal of Rheumatology
Issue number6
StatePublished - 1986
Externally publishedYes


Dive into the research topics of 'Immunogenetics of juvenile chronic arthritis in Israel'. Together they form a unique fingerprint.

Cite this