TY - JOUR
T1 - Immunocompetence in pregnancy
T2 - production of interleukin-2 by peripheral blood lymphocytes.
AU - Hauser, G. J.
AU - Lidor, A.
AU - Zakuth, V.
AU - Rosenberg, H.
AU - Bino, T.
AU - David, M. P.
AU - Spirer, Z.
PY - 1987
Y1 - 1987
N2 - Pregnancy is a natural allograft and the mechanisms for its non-rejection are obscure. Depression of maternal cellular immunity was suggested as a possible explanation. Interleukin-2(IL-2) is a lymphokine release from OKT4+ lymphocyte. This factor has a crucial role in the proliferation and differentiation of T cell subsets, and controls functions associated with immune rejection mechanisms. We therefore examined the ability of lymphocytes from women in the 3 trimesters of pregnancy to produce IL-2 in culture. Mononuclear cells were cultured with PHA for 48 h. The IL-2-containing supernatant was added to and supported the proliferation of an IL-2 dependent T cell line. Proliferation of this line indicated the IL-2 content of the added supernatant. Using this assay, IL-2 production in all 3 trimesters of pregnancy was adequate and comparable to that of lymphocytes from non-pregnant women. These results suggest that the proposed defect in cellular immunity during pregnancy is not mediated by an inability of the lymphocytes to produce IL-2.
AB - Pregnancy is a natural allograft and the mechanisms for its non-rejection are obscure. Depression of maternal cellular immunity was suggested as a possible explanation. Interleukin-2(IL-2) is a lymphokine release from OKT4+ lymphocyte. This factor has a crucial role in the proliferation and differentiation of T cell subsets, and controls functions associated with immune rejection mechanisms. We therefore examined the ability of lymphocytes from women in the 3 trimesters of pregnancy to produce IL-2 in culture. Mononuclear cells were cultured with PHA for 48 h. The IL-2-containing supernatant was added to and supported the proliferation of an IL-2 dependent T cell line. Proliferation of this line indicated the IL-2 content of the added supernatant. Using this assay, IL-2 production in all 3 trimesters of pregnancy was adequate and comparable to that of lymphocytes from non-pregnant women. These results suggest that the proposed defect in cellular immunity during pregnancy is not mediated by an inability of the lymphocytes to produce IL-2.
UR - http://www.scopus.com/inward/record.url?scp=0023477888&partnerID=8YFLogxK
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AN - SCOPUS:0023477888
SN - 1043-6995
VL - 1
SP - 39
EP - 42
JO - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc
JF - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc
ER -