Immune responses elicited by vaccinations with Candida albicans ribosomes in cyclophosphamide treated animals

Esther Segal*, Hana Sandovsky-Losica, Sarah Nussbaum

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

This study describes humoral and cell mediated immune (CMI) responses detected in cyclophosphamide (CY) treated animals who were vaccinated with Candida albicans ribosomes and were protected against systemic candidiasis (previous study). Mice treated with CY and vaccinated with C. albicans ribosomes revealed CMI responses towards the ribosomes as measured in vivo by the foot pad swelling test and in vitro by the lymphocyte transformation assay. Both reactions were higher in CY treated and ribosome vaccinated mice than in controls (mice that were only vaccinated). Humoral immune responses were measured by the enzyme linked immunosorbent assay (ELISA). Anti ribosomal antibody titer contrary to the CMI responses was lower in CY treated animals than in non treated controls. These data point to a possible explanation of the mechanisms underlying the ribosomal vaccinations in CY treated hosts, and show the potential of such vaccinations in compromised individuals.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalMycopathologia
Volume89
Issue number2
DOIs
StatePublished - Feb 1985

Keywords

  • C. albicans ribosomal vaccinations
  • CY treated mice
  • immune responses

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