TY - JOUR
T1 - Immune Reproductive Failure
T2 - Effect of Nonspecific Immunostimulation in Mouse Model
AU - STRASSBURGER, D.
AU - CARP, H.
AU - TODER, V.
PY - 1992
Y1 - 1992
N2 - ABSTRACT: There is much evidence that pregnancy loss may be immunologically mediated. Failure of the maternal immune system to actively support the pregnancy may be responsible for its demise. Potentiation of immune functions has been attempted in humans; however, the success of immunotherapy is still not clear. Thus immunotherapy experiments in mouse models are important. Nonspecific immunostimulation with complete Freund adjuvant (CFA) was shown in our laboratory to reverse the tendency to fetal loss in the CBA/J × DBA/2J mouse combination. CFA elevates the non‐T lymphocyte population, decreases T‐cell secreted lymphokines, and enhances macrophage‐secreted monokines. However, a relationship between these changes and a beneficial effect of CFA on reproductive performance has to be proved. Information obtained from nonspecific immunopotentiation in the CBA/J‐DBA/ 2J model may contribute the assessment of nonspecific immunotherapy in humans. 1992 Munksgaard
AB - ABSTRACT: There is much evidence that pregnancy loss may be immunologically mediated. Failure of the maternal immune system to actively support the pregnancy may be responsible for its demise. Potentiation of immune functions has been attempted in humans; however, the success of immunotherapy is still not clear. Thus immunotherapy experiments in mouse models are important. Nonspecific immunostimulation with complete Freund adjuvant (CFA) was shown in our laboratory to reverse the tendency to fetal loss in the CBA/J × DBA/2J mouse combination. CFA elevates the non‐T lymphocyte population, decreases T‐cell secreted lymphokines, and enhances macrophage‐secreted monokines. However, a relationship between these changes and a beneficial effect of CFA on reproductive performance has to be proved. Information obtained from nonspecific immunopotentiation in the CBA/J‐DBA/ 2J model may contribute the assessment of nonspecific immunotherapy in humans. 1992 Munksgaard
KW - Infertility
KW - complete Freund adjuvant
KW - immunotherapy
KW - mouse model
UR - http://www.scopus.com/inward/record.url?scp=0027056813&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.1992.tb00813.x
DO - 10.1111/j.1600-0897.1992.tb00813.x
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AN - SCOPUS:0027056813
SN - 1046-7408
VL - 28
SP - 274
EP - 276
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 3-4
ER -
