Immune activation in non-treated suicidal major depression

Shlomo Mendlovic; Edna Mozes; Eran Eilat; Adiel Doron; Joseph Lereya; Vera Zakuth; Zvi Spirer

doi:10.1016/S0165-2478(98)00145-X

Immune activation in non-treated suicidal major depression

Shlomo Mendlovic^*, Edna Mozes, Eran Eilat, Adiel Doron, Joseph Lereya, Vera Zakuth, Zvi Spirer

^*Corresponding author for this work

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Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is associated with most of autoimmune diseases. It is thus speculated that Th1 activation in suicidal depression may reflect a unique form of autoimmune suicide.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	Immunology Letters
Volume	67
Issue number	2
DOIs	https://doi.org/10.1016/S0165-2478(98)00145-X
State	Published - 1 Apr 1999

Keywords

Depression
Immune activation
NK cells
Suicide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-2478(98)00145-X

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title = "Immune activation in non-treated suicidal major depression",

abstract = "In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is associated with most of autoimmune diseases. It is thus speculated that Th1 activation in suicidal depression may reflect a unique form of autoimmune suicide.",

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AU - Mendlovic, Shlomo

AU - Mozes, Edna

AU - Eilat, Eran

AU - Doron, Adiel

AU - Lereya, Joseph

AU - Zakuth, Vera

AU - Spirer, Zvi

PY - 1999/4/1

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N2 - In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is associated with most of autoimmune diseases. It is thus speculated that Th1 activation in suicidal depression may reflect a unique form of autoimmune suicide.

AB - In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is associated with most of autoimmune diseases. It is thus speculated that Th1 activation in suicidal depression may reflect a unique form of autoimmune suicide.

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KW - Immune activation

KW - NK cells

KW - Suicide

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Immune activation in non-treated suicidal major depression

Abstract

Keywords

UN SDGs

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