TY - JOUR
T1 - Imipenem-resistant Pseudomonas aeruginosa
T2 - Risk factors and antibiotic susceptibility patterns
AU - Troillet, Nicolas
AU - Samore, Matthew H.
AU - Carmeli, Yehuda
PY - 1997
Y1 - 1997
N2 - Potential risk factors for the detection of imipenem-resistant Pseudomonas aeruginosa in hospitalized patients were assessed by a case- control study. Forty patients whose first P. aeruginosa isolate was resistant or intermediate to imipenem were more likely than 387 controls to have received imipenem (odds ratio [OR] = 16.9; P < .0001) and to have undergone organ transplantation (OR = 3.9; P = .008). No significant difference was found for treatments with other antibiotics, other underlying diseases, demographic characteristics, different exposures to the hospital environment, or the culture site. Imipenem-resistant P. aeruginosa isolates were more likely to be resistant to other common antipseudomonal agents than were imipenem-susceptible isolates. It is concluded that treatment with imipenem, but not with other β-lactam drugs, is a major risk factor for the detection of imipenem-resistant P. aeruginosa in hospitalized patients, that these organisms may relatively often be resistant to other antipseudomonal agents, and that the hospital environment per so might not play a major role in their epidemiology.
AB - Potential risk factors for the detection of imipenem-resistant Pseudomonas aeruginosa in hospitalized patients were assessed by a case- control study. Forty patients whose first P. aeruginosa isolate was resistant or intermediate to imipenem were more likely than 387 controls to have received imipenem (odds ratio [OR] = 16.9; P < .0001) and to have undergone organ transplantation (OR = 3.9; P = .008). No significant difference was found for treatments with other antibiotics, other underlying diseases, demographic characteristics, different exposures to the hospital environment, or the culture site. Imipenem-resistant P. aeruginosa isolates were more likely to be resistant to other common antipseudomonal agents than were imipenem-susceptible isolates. It is concluded that treatment with imipenem, but not with other β-lactam drugs, is a major risk factor for the detection of imipenem-resistant P. aeruginosa in hospitalized patients, that these organisms may relatively often be resistant to other antipseudomonal agents, and that the hospital environment per so might not play a major role in their epidemiology.
UR - http://www.scopus.com/inward/record.url?scp=0030729148&partnerID=8YFLogxK
U2 - 10.1086/516092
DO - 10.1086/516092
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 9402364
AN - SCOPUS:0030729148
SN - 1058-4838
VL - 25
SP - 1094
EP - 1098
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -