Imipenem-resistant Pseudomonas aeruginosa: Risk factors and antibiotic susceptibility patterns

Nicolas Troillet*, Matthew H. Samore, Yehuda Carmeli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

161 Scopus citations

Abstract

Potential risk factors for the detection of imipenem-resistant Pseudomonas aeruginosa in hospitalized patients were assessed by a case- control study. Forty patients whose first P. aeruginosa isolate was resistant or intermediate to imipenem were more likely than 387 controls to have received imipenem (odds ratio [OR] = 16.9; P < .0001) and to have undergone organ transplantation (OR = 3.9; P = .008). No significant difference was found for treatments with other antibiotics, other underlying diseases, demographic characteristics, different exposures to the hospital environment, or the culture site. Imipenem-resistant P. aeruginosa isolates were more likely to be resistant to other common antipseudomonal agents than were imipenem-susceptible isolates. It is concluded that treatment with imipenem, but not with other β-lactam drugs, is a major risk factor for the detection of imipenem-resistant P. aeruginosa in hospitalized patients, that these organisms may relatively often be resistant to other antipseudomonal agents, and that the hospital environment per so might not play a major role in their epidemiology.

Original languageEnglish
Pages (from-to)1094-1098
Number of pages5
JournalClinical Infectious Diseases
Volume25
Issue number5
DOIs
StatePublished - 1997
Externally publishedYes

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