Imaging findings in Laron syndrome

Liora Kornreich*, Zvi Laron

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The imaging findings by the various modalities (X-rays, CT, and MR) in our cohort of Laron Syndrome patients, during 50 years of follow-up, are described. The face, the orbits and the base of skull are small with underdeveloped paranasal sinuses and mastoids. The skull is relatively large for the small body. Frequently occurring is the anomaly of the dens of the os odontoideum type. Reduced dimensions of the larynx and oropharynx result in propensity for sleep apnea.The brain presents no specific pathological findings, and no abnormalities of the pituitary gland are detected. In the spine and appendicular skeleton every depicted bone is proportionally small. In the cervical spine this results in spinal stenosis. In the lumbar spine, the spinal canal is narrow as well. There is a tendency for early osteoarthritic changes. No signs of osteopenia are detected. There is marked retardation of bone age.

Original languageEnglish
Title of host publicationLaron Syndrome - From Man to Mouse
Subtitle of host publicationLessons from Clinical and Experimental Experience
PublisherSpringer Berlin Heidelberg
Number of pages25
ISBN (Print)9783642111822
StatePublished - 2011


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