Imaging approaches to hematopoietic stem and progenitor cell function and engraftment

Nadir Askenasy*, Jerry Stein, Daniel L. Farkas

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Cell tracking in vivo continues to provide significant insights into hematopoietic cell function and donor cell engraftment after transplantation. The combination of proliferation tracking dyes and induced expression of reporters with advanced imaging modalities has led to better understanding of qualitative and quantitative aspects of hematopoietic cells' homing, seeding and engraftment. Currently, there is no single technique that allows in vivo tracking of cells with molecular resolution, thus several techniques need to be combined. Recent developments promise better implementation of non-invasive imaging modalities to study functional and molecular characteristics of stem cells.

Original languageEnglish
Pages (from-to)713-738
Number of pages26
JournalImmunological Investigations
Volume36
Issue number5-6
DOIs
StatePublished - Sep 2007
Externally publishedYes

Funding

FundersFunder number
Leah and Edward Frankel Supporting Foundation
U.S. Navy Bureau of Medicine and Surgery

    Keywords

    • Bone marrow transplantation
    • CFSE
    • Cell tracking
    • Engraftment
    • Hematopoietic progenitor cells
    • Homing
    • In vivo imaging
    • PKH dyes
    • Seeding

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