@article{f7b4049f8031492baea078bbe599bbc1,
title = "Imaging analysis of collagen fiber networks in cusps of porcine aortic valves: effect of their local distribution and alignment on valve functionality",
abstract = "Abstract: The cusps of native aortic valve (AV) are composed of collagen bundles embedded in soft tissue, creating a heterogenic tissue with asymmetric alignment in each cusp. This study compares native collagen fiber networks (CFNs) with a goal to better understand their influence on stress distribution and valve kinematics. Images of CFNs from five porcine tricuspid AVs are analyzed and fluid-structure interaction models are generated based on them. Although the valves had similar overall kinematics, the CFNs had distinctive influence on local mechanics. The regions with dilute CFN are more prone to damage since they are subjected to higher stress magnitudes.",
keywords = "Collagen fibers, aortic valves, fluid-structure interaction, numerical model, porcine specific",
author = "Mor Mega and Gil Marom and Rotem Halevi and Ashraf Hamdan and Danny Bluestein and Rami Haj-Ali",
note = "Publisher Copyright: {\textcopyright} 2015 Taylor & Francis.",
year = "2015",
month = jul,
day = "3",
doi = "10.1080/10255842.2015.1088009",
language = "אנגלית",
volume = "19",
pages = "1002--1008",
journal = "Computer Methods in Biomechanics and Biomedical Engineering",
issn = "1025-5842",
publisher = "Informa Healthcare",
number = "9",
}