TY - JOUR
T1 - IL-3-LA production by mononuclear cells of patients with multiple sclerosis
T2 - Effect of treatment with intravenous immunoglobulins
AU - Djaldetti, R.
AU - Achiron, A.
AU - Ziv, I.
AU - Djaldetti, M.
AU - Melamed, E.
AU - Fishman, P.
PY - 1995
Y1 - 1995
N2 - IL-3-like activity (IL-3-LA) is a growth factor that stimulates stem cell maturation. We examined the production of IL-3-LA by peripheral blood mononuclear cells of 10 patients with relapsing-remitting multiple sclerosis (MS) following one year of treatment with intravenous immunoglobulins (IVIG). The results were compared with those obtained in 13 age- and sex-matched untreated patients with relapsing-remitting MS and in 14 healthy controls. IL-3-LA was assayed using the IL-3-dependent 32-D-cl-23 murine cell line. IL-3-LA production was 60% higher in untreated MS patients than in healthy controls (134±19 u/ml and 78.7±15.9 u/ml, respectively; p<0.01), and lower in patients treated with IVIG than in untreated patients (101.4±4.9 u/ml; p<0.02). IL-3-LA production also decreased after incubation of mononuclear cells with IVIG of both untreated MS patients and controls. This study indicates a possible beneficial effect of IVIG on the immunological status of MS patients.
AB - IL-3-like activity (IL-3-LA) is a growth factor that stimulates stem cell maturation. We examined the production of IL-3-LA by peripheral blood mononuclear cells of 10 patients with relapsing-remitting multiple sclerosis (MS) following one year of treatment with intravenous immunoglobulins (IVIG). The results were compared with those obtained in 13 age- and sex-matched untreated patients with relapsing-remitting MS and in 14 healthy controls. IL-3-LA was assayed using the IL-3-dependent 32-D-cl-23 murine cell line. IL-3-LA production was 60% higher in untreated MS patients than in healthy controls (134±19 u/ml and 78.7±15.9 u/ml, respectively; p<0.01), and lower in patients treated with IVIG than in untreated patients (101.4±4.9 u/ml; p<0.02). IL-3-LA production also decreased after incubation of mononuclear cells with IVIG of both untreated MS patients and controls. This study indicates a possible beneficial effect of IVIG on the immunological status of MS patients.
KW - IL-3-Like Activity
KW - Intravenous Immunoglobulins
KW - Multiple Sclerosis
UR - http://www.scopus.com/inward/record.url?scp=0029090345&partnerID=8YFLogxK
U2 - 10.3109/08820139509060704
DO - 10.3109/08820139509060704
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 8543340
AN - SCOPUS:0029090345
SN - 0882-0139
VL - 24
SP - 765
EP - 773
JO - Immunological Investigations
JF - Immunological Investigations
IS - 5
ER -