IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells

Kristine E. Nograles, Lisa C. Zaba, Avner Shemer, Judilyn Fuentes-Duculan, Irma Cardinale, Toyoko Kikuchi, Michal Ramon, Reuven Bergman, James G. Krueger, Emma Guttman-Yassky

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of TH17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear. Objective: To examine differences in IL-23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets in AD. Methods: Skin biopsies and peripheral blood were collected from patients with chronic AD (n = 12) and psoriasis (n = 13). Relative frequencies of CD4+ and CD8+ T-cell subsets within these 2 compartments were examined by intracellular cytokine staining and flow cytometry. Results: In peripheral blood, no significant difference was found in percentages of different T-cell subsets between these diseases. In contrast, psoriatic skin had significantly increased frequencies of TH1 and TH17 T cells compared with AD, whereas TH2 T cells were significantly elevated in AD. Distinct IL-22-producing CD4+ and CD8+ T-cell populations were significantly increased in AD skin compared with psoriasis. IL-22+CD8+ T-cell frequency correlated with AD disease severity. Conclusion: Our data established that T cells could independently express IL-22 even with low expression levels of IL-17. This argues for a functional specialization of T cells such that "T17" and "T22" T-cells may drive different features of epidermal pathology in inflammatory skin diseases, including induction of antimicrobial peptides for "T17" T cells and epidermal hyperplasia for "T22" T-cells. Given the clinical correlation with disease severity, further characterization of "T22" T cells is warranted, and may have future therapeutic implications.

Original languageEnglish
Pages (from-to)1244-1252.e2
JournalJournal of Allergy and Clinical Immunology
Volume123
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • Atopic dermatitis
  • IL-17
  • IL-22
  • psoriasis
  • T22
  • T17

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