IL-2 and IL-6 secretion in dementia: correlation with type and severity of disease

M. Huberman, B. Sredni, L. Stern, E. Kott, F. Shalit

Research output: Contribution to journalArticlepeer-review

Abstract

The production of interleukin-2 (IL-2) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (MNC) was assessed in patients with Alzheimer's disease (AD) who were subdivided into two groups - mild and moderately-severe - according to the severity of the disease, probable vascular dementia (VaD) patients and elderly control subjects. No differences in IL-2 secretion were found between mild AD patients and controls. However, there was a significant increase in IL-2 production both in the moderately-severe AD group and in the VaD group. IL-6 levels in AD patients of both groups were similar and significantly higher than those of VaD and controls. Our results suggest that increased levels of IL-2-production correlate with severity of the dementia, whereas increased levels of IL-6 production seem to be related to AD and thus may play a role in AD pathogenesis.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalJournal of the Neurological Sciences
Volume130
Issue number2
DOIs
StatePublished - Jun 1995
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Interleukin-2
  • Interleukin-6
  • Vascular dementia

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