IL-17 promotes murine lupus

Gil Amarilyo, Elaine V. Lourenço, Fu Dong Shi, Antonio La Cava

Research output: Contribution to journalArticlepeer-review

Abstract

The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17-sufficient wild-type mice did not occur in IL-17-deficient mice, which were protected from development of lupus autoantibodies and glomerulonephritis. The protection from SLE in IL-17-deficient mice was associated with a reduced frequency of CD3+ CD4-CD8- double-negative T cells and an expansion of CD4+ regulatory T cells, and did not depend on Stat-1 signaling. These data affirm the key role of IL-17 in the pathogenesis of SLE and strengthen the support for IL-17 blockade in the therapy of SLE.

Original languageEnglish
Pages (from-to)540-543
Number of pages4
JournalJournal of Immunology
Volume193
Issue number2
DOIs
StatePublished - 15 Jul 2014
Externally publishedYes

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