IL-1β and IL-3-like activity in preterm infants

H. Bessler; L. Sirota; I. Notti; F. Dulitzky; M. Djaldetti

doi:10.1111/j.1365-2249.1993.tb05902.x

IL-1β and IL-3-like activity in preterm infants

H. Bessler, L. Sirota, I. Notti, F. Dulitzky, M. Djaldetti^*

^*Corresponding author for this work

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The capacity of peripheral blood mononuclear cells (PBMC) of preterm neonates to release IL-1β and IL-3-like activity (IL-3-LA) has been investigated. In the present study it was found that this capacity is significantly lower than that of their mothers and of control adults. In addition, the results showed that preterm serum has a lower stimulatory effect on IL-1β production and an inhibitory effect on IL-3-LA secretion by PBMC of adult controls, in comparison with maternal and adult sera. These findings suggest an additional feedback mechanism for control of haematopoiesis in premature neonates. It is possible that the lower production of IL-1β and IL-3-LA may be involved in the increased susceptibility to infections of preterm newborns.

Original language	English
Pages (from-to)	320-324
Number of pages	5
Journal	Clinical and Experimental Immunology
Volume	91
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2249.1993.tb05902.x
State	Published - 1993
Externally published	Yes

Keywords

IL-1β
IL-3-LA
peripheral blood mononuclear cells
preterm infants

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10.1111/j.1365-2249.1993.tb05902.x

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abstract = "The capacity of peripheral blood mononuclear cells (PBMC) of preterm neonates to release IL-1β and IL-3-like activity (IL-3-LA) has been investigated. In the present study it was found that this capacity is significantly lower than that of their mothers and of control adults. In addition, the results showed that preterm serum has a lower stimulatory effect on IL-1β production and an inhibitory effect on IL-3-LA secretion by PBMC of adult controls, in comparison with maternal and adult sera. These findings suggest an additional feedback mechanism for control of haematopoiesis in premature neonates. It is possible that the lower production of IL-1β and IL-3-LA may be involved in the increased susceptibility to infections of preterm newborns.",

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AU - Bessler, H.

AU - Sirota, L.

AU - Notti, I.

AU - Dulitzky, F.

AU - Djaldetti, M.

PY - 1993

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AB - The capacity of peripheral blood mononuclear cells (PBMC) of preterm neonates to release IL-1β and IL-3-like activity (IL-3-LA) has been investigated. In the present study it was found that this capacity is significantly lower than that of their mothers and of control adults. In addition, the results showed that preterm serum has a lower stimulatory effect on IL-1β production and an inhibitory effect on IL-3-LA secretion by PBMC of adult controls, in comparison with maternal and adult sera. These findings suggest an additional feedback mechanism for control of haematopoiesis in premature neonates. It is possible that the lower production of IL-1β and IL-3-LA may be involved in the increased susceptibility to infections of preterm newborns.

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IL-1β and IL-3-like activity in preterm infants

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Keywords

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