IGF, IGF receptor and overgrowth syndromes

Itay Bentov, Haim Werner

Research output: Contribution to journalReview articlepeer-review

Abstract

The insulin-like growth factors are a family of growth factors, binding proteins and receptors that are involved in normal growth as well as in a number of pathological states. Overgrowth syndromes are a group of disorders characterized by a phenotype of excessive somatic and visceral growth. In addition, patients suffering from overgrowth syndromes are predisposed to develop cancer. Several specific defects linked to the insulin-like growth factor system were elucidated for a group of these disorders, including Simpson-Golabi-Behmel syndrome, Bannayan-Ruvalcaba-Riley syndrome and Beckwith-Wiedemann syndrome. The aim of this review is to examine recent data linking the phenotype of overgrowth syndromes, visceral growth and increased risk of neoplasia, with the molecular machinery of the IGF system.

Original languageEnglish
Pages (from-to)352-360
Number of pages9
JournalPediatric Endocrinology Reviews
Volume1
Issue number4
StatePublished - Jun 2004

Keywords

  • Bannayan-Ruvalcaba-Riley syndrome
  • Beckwith-Wiedemann syndrome
  • IGF-1
  • IGF-1 receptor
  • IGF-2
  • Overgrowth
  • Simpson-Golabi- Behmel syndrome
  • Wilms' tumor

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