IGF-I receptor 275124A>C (rs1464430) polymorphism and athletic performance

Sigal Ben-Zaken, Yoav Meckel, Dan Nemet, Alon Eliakim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: To examine the prevalence of the Insulin-Like Growth Factor-I receptor (IGF-IR) 275124A>C polymorphism, known to be associated with exercise-related cardiac hypertrophy, among elite endurance and power athletes. Design: One hundred and fifty-nine athletes (118 men and 41 women, age: 35.9. ±. 12.2 yrs) participated in the study. Methods: We hypothesized that presence of the A allele will be significantly more common among endurance athletes (. n=. 77) compared to power athletes (. n=. 82) and non-physically active controls (. n=. 68). Athletes within each group were further divided according to their individual best performance into elite athletes (those who had represented the country in international track-and-field or triathlon competitions or in the Olympic Games) and national-level athletes. Results: The prevalence of the AA genotype was significantly higher (. p<. 0.05) in the endurance athletes group (49%) compared to the power athletes group (33%), but did not differ from the control group (46%). There was no significant difference in the prevalence of the AA genotype between elite and national level endurance athletes (44% versus 52%, respectively). In contrast, among power athletes, the prevalence of the AA genotype was significantly lower in the elite compared to national level athletes (17% versus 42%, respectively; p<. 0.05). Conclusions: The results of the present study may suggest that the IGF-IR AA polymorphism is beneficial for endurance-type sports, but is not associated with elite endurance performance. In contrast, the presence of the AA genotype may be a disadvantage in power sports. All together the results of the present study suggest that IGF-IR polymorphism may differentiate between the two edges of the endurance-power athletic performance spectrum.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalJournal of Science and Medicine in Sport
Issue number3
StatePublished - 1 May 2015


  • Endurance athletes
  • Exercise genetics
  • Growth factors
  • Power athletes


Dive into the research topics of 'IGF-I receptor 275124A>C (rs1464430) polymorphism and athletic performance'. Together they form a unique fingerprint.

Cite this