IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome

Zvi Laron*, Rivka Kauli, Lena Lapkina, Haim Werner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.

Original languageEnglish
Pages (from-to)123-133
Number of pages11
JournalMutation Research - Reviews in Mutation Research
Volume772
DOIs
StatePublished - Apr 2017

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