TY - JOUR
T1 - IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome
AU - Laron, Zvi
AU - Kauli, Rivka
AU - Lapkina, Lena
AU - Werner, Haim
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/4
Y1 - 2017/4
N2 - Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.
AB - Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.
UR - http://www.scopus.com/inward/record.url?scp=84996956348&partnerID=8YFLogxK
U2 - 10.1016/j.mrrev.2016.08.002
DO - 10.1016/j.mrrev.2016.08.002
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AN - SCOPUS:84996956348
SN - 1383-5742
VL - 772
SP - 123
EP - 133
JO - Mutation Research - Reviews in Mutation Research
JF - Mutation Research - Reviews in Mutation Research
ER -