TY - JOUR
T1 - Idiopathic osteonecrosis in an adult with familial protein S deficiency and hyperhomocysteinemia
AU - Elishkewich, K.
AU - Kaspi, D.
AU - Shapira, I.
AU - Meites, D.
AU - Berliner, Shlomo
PY - 2001
Y1 - 2001
N2 - We describe a 36-year-old man with familial protein S deficiency and homozygosity to the methylene tetrahydrofolate reductase (MTHFR) thermolabile variant who had a stroke followed by an episode of idiopathic osteonecrosis that was successfully managed by surgical core decompression. The patient's symptomatic thrombophilia, as well as that of several of his first-degree relatives who also had thrombotic events, raises the possibility that the thrombophilia was a contributing factor to the development of his osteonecrosis.
AB - We describe a 36-year-old man with familial protein S deficiency and homozygosity to the methylene tetrahydrofolate reductase (MTHFR) thermolabile variant who had a stroke followed by an episode of idiopathic osteonecrosis that was successfully managed by surgical core decompression. The patient's symptomatic thrombophilia, as well as that of several of his first-degree relatives who also had thrombotic events, raises the possibility that the thrombophilia was a contributing factor to the development of his osteonecrosis.
KW - Hyperhomocysteinemia
KW - Osteonecrosis
KW - Protein S deficiency
UR - http://www.scopus.com/inward/record.url?scp=0034747825&partnerID=8YFLogxK
U2 - 10.1097/00001721-200110000-00006
DO - 10.1097/00001721-200110000-00006
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C2 - 11685042
AN - SCOPUS:0034747825
SN - 0957-5235
VL - 12
SP - 547
EP - 550
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 7
ER -
