Idiopathic liver function test abnormality in pregnancy is associated with assisted reproduction techniques

Uri Kopylov, Benjamin Avidan, Neofytos P. Papageorgiou, Lior H. Katz, Eyal Sivan, Eyal Zimlichman, Haya Hussein, Yaakov Maor

Research output: Contribution to journalArticlepeer-review


Objective: To examine the prevalence, etiology, risk factors, and outcomes of liver abnormality in pregnancy, in a tertiary medical center, and to study the potential impact of artificial reproduction techniques (ART) on the incidence and the outcome of pregnancy-related liver abnormality. Design: A retrospective case-control study using an electronic database and patients' files. Setting: Tertiary referral center. Patient(s): Women in the third trimester of pregnancy who were hospitalized for delivery. Intervention(s): None. Main Outcome Measure(s): Development of significant elevation of alanine aminotransferase (ALT ≥100 IU/L). Secondary outcomes included development of maternal and fetal complications. Result(s): The upper limit of normal of ALT was ≥1.5 times and it occurred in 440 (1.6%) pregnancies; of those, 228 (0.8%) had ALT ≥100 IU/L. The etiology of significant liver test abnormality was idiopathic in 47% of patients. Compared with spontaneous pregnancies (295/23,793), ART was significantly associated with liver test abnormality (145/4, 520). The presence of ALT ≥100 IU/L in the third trimester was associated with higher rates of cesarean sections, prematurity, low birthweight, and fetal complications. Conclusion(s): A definite etiology was not determined in about half of pregnancy-Associated liver test abnormality. The ART was significantly associated with liver test elevation. Significant liver test abnormality in the third trimester may have an impact on maternal and fetal/neonatal outcomes.

Original languageEnglish
Pages (from-to)377-381.e3
JournalFertility and Sterility
Issue number2
StatePublished - Feb 2013
Externally publishedYes


  • Assisted reproduction techniques
  • intrahepatic cholestatis of pregnancy
  • liver test abnormality
  • preeclampsia


Dive into the research topics of 'Idiopathic liver function test abnormality in pregnancy is associated with assisted reproduction techniques'. Together they form a unique fingerprint.

Cite this