TY - JOUR
T1 - Idiopathic aplastic anemia
T2 - Diagnosis and classification
AU - Dolberg, Osnat Jarchowsky
AU - Levy, Yair
PY - 2014/4
Y1 - 2014/4
N2 - Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.
AB - Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.
KW - Aplastic anemia
KW - Autoimmunity
KW - Immunosuppressive therapy
KW - Pancytopenia
UR - http://www.scopus.com/inward/record.url?scp=84896319709&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2014.01.014
DO - 10.1016/j.autrev.2014.01.014
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C2 - 24424170
AN - SCOPUS:84896319709
SN - 1568-9972
VL - 13
SP - 569
EP - 573
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 4-5
ER -