TY - JOUR
T1 - Identification of palindromic sequences recognized by restriction endonucleases, as based on the tabularized sequencing data for seven viral and plasmid DNAs
AU - Fuchs, Camil
AU - Rosenvold, Eric C.
AU - Honigman, Alik
AU - Szybalski, Waclaw
N1 - Funding Information:
We are greatly obliged to Dr. R. Blakesley for many helpful comments and corrections. Drs. S.M. Weissman, W. Fiers, H. Saito, J.G. Schoenmakers and M. van Montagu supplied us with unpublished data or data prior to publication. This work was supported by program-project grants from the National Cancer Institute (CA-23076 and CA-07175).
PY - 1980
Y1 - 1980
N2 - Computer search of DNA sequences for phages φX174, G4, M13 and fd, plasmids pBR322 and pA03, and virus SV40, was employed to prepare tables specifying the size classes and frequencies of DNA segments located between all possible tetra-, penta- and hexanucleotide palindromes. As described earlier (Fuchs et al., 1978), these tables permit identifying sequences recognized by most of the restriction endonucleases. The effect of sequencing errors on the accuracy of the present identification method is evaluated. Only four of the 224 listed sequences do not appear in any of the seven DNAs, leading to discussion (see Appendix) on the natural sequence distribution.
AB - Computer search of DNA sequences for phages φX174, G4, M13 and fd, plasmids pBR322 and pA03, and virus SV40, was employed to prepare tables specifying the size classes and frequencies of DNA segments located between all possible tetra-, penta- and hexanucleotide palindromes. As described earlier (Fuchs et al., 1978), these tables permit identifying sequences recognized by most of the restriction endonucleases. The effect of sequencing errors on the accuracy of the present identification method is evaluated. Only four of the 224 listed sequences do not appear in any of the seven DNAs, leading to discussion (see Appendix) on the natural sequence distribution.
KW - Recombinant DNA
KW - bacteriophages φ X174, G4, fd, M13
KW - computer search
KW - pA03
KW - plasmids pBR322
KW - tetra-, penta-, hexanucleotides
KW - virus SV40
UR - http://www.scopus.com/inward/record.url?scp=0018963831&partnerID=8YFLogxK
U2 - 10.1016/0378-1119(80)90156-0
DO - 10.1016/0378-1119(80)90156-0
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AN - SCOPUS:0018963831
SN - 0378-1119
VL - 10
SP - 357
EP - 370
JO - Gene
JF - Gene
IS - 4
ER -