@article{e5030cf442d14574856cb6b4175389c7,
title = "Identification of let-7-regulated oncofetal genes",
abstract = "MicroRNAs (miRNA) are small RNA molecules of ∼20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1 has growth-promoting activities through stabilization of c-myc mRNA. We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth and motility of tumor cells, and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets. Our data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1. LOGs could be novel therapeutic targets and potential biomarkers for cancer treatment.",
author = "Benjamin Boyerinas and Park, {Sun Mi} and Noam Shomron and Hedegaard, {Mads M.} and Jeppe Vinther and Andersen, {Jens S.} and Christine Feig and Jinbo Xu and Burge, {Christopher B.} and Peter, {Marcus E.}",
year = "2008",
month = apr,
day = "15",
doi = "10.1158/0008-5472.CAN-08-0264",
language = "אנגלית",
volume = "68",
pages = "2587--2591",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "8",
}