Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders

Ismael Chehaibou, Moritz Pettenkofer, Andrea Govetto, Gilad Rabina, Srini Vas R. Sadda, Jean Pierre Hubschman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions. Methods: Consecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation on optical coherence tomography (OCT) were enrolled in this cross-sectional study. Included patients were divided into two groups: vitreoretinal interface pathologies group or retinal diseases group. Presence of epiretinal proliferation and its localization within the 9 macular sectors, as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS), were assessed on OCT. Results: 77 eyes from 69 patients demonstrated epiretinal proliferation on OCT. The most frequently involved ETDRS sector was the 1-mm central subfield, followed by inner temporal and inner nasal sectors. Localization of epiretinal proliferation correlated with the presence of any retinal abnormalities in the same quadrant (r = 0.962; P < 0.0001). 31 eyes (40.3%) demonstrated symptomatic vitreoretinal interface pathologies including lamellar macular hole, full-thickness macular hole, epiretinal membrane and history of macular peeling. 46 eyes (59.7%) manifested various retinal diseases, including age-related macular degeneration, diabetic retinopathy, refractory macular edema, vein occlusion and high myopia. Conclusions: Epiretinal proliferation was noted in several retinal conditions and not limited only to full-thickness and lamellar macular holes. Different mechanisms affecting retinal homeostasis might trigger Müller cells dysregulation, potentially leading to abnormal retinal remodeling.

Original languageEnglish
Article number31
JournalInternational Journal of Retina and Vitreous
Issue number1
StatePublished - 10 Jul 2020


FundersFunder number
Hess Foundation
Research to Prevent Blindness


    • Epiretinal membrane
    • Epiretinal proliferation
    • Full-thickness macular holes
    • Lamellar hole-associated epiretinal proliferation
    • Lamellar macular holes
    • Macular edema
    • Müller glial cells
    • Spectral-domain optical coherence tomography


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