Identification of an interleukin 2-like substance as a factor cytotoxic to oligodendrocytes and associated with central nervous system regeneration

S. Eitan, R. Zisling, A. Cohen, M. Belkin, D. L. Hirschberg, M. Lotan, M. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Axons of the central nervous system in adult mammals do not regenerate spontaneously after injury, partly because of the presence of oligodendrocytes that inhibit axonal growth. This is not the case in lower vertebrates (e.g., in fish), where regeneration of the optic nerve does occur spontaneously and has been correlated with the presence of factors cytotoxic to oligodendrocytes. The present study provides evidence that the substance originating from the fish optic nerves, which is cytotoxic to oligodendrocytes, is an interleukin 2-like substance.

Original languageEnglish
Pages (from-to)5442-5446
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number12
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • cytotoxicity
  • lymphokines
  • nerve injury
  • nerve regeneration

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