Identification and screening of carbapenemase-producing Enterobacteriaceae

P. Nordmann*, M. Gniadkowski, C. G. Giske, L. Poirel, N. Woodford, V. Miriagou, M. Akova, T. Naas, H. Seifert, D. Livermore, P. Bogaerts, Y. Glupczynski, R. Canton, M. Rossolini G., A. Adler, Y. Carmeli, S. Navon-Venezia, O. Samuelsen, G. Cornaglia

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.

Original languageEnglish
Pages (from-to)432-438
Number of pages7
JournalClinical Microbiology and Infection
Volume18
Issue number5
DOIs
StatePublished - 1 May 2012

Funding

FundersFunder number
Institut national de la santé et de la recherche médicaleU914
European Society of Clinical Microbiology and Infectious Diseases

    Keywords

    • Antibiotic
    • Carbapenem
    • Gram-negatives
    • Resistance
    • β-lactams

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