Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene

Iris Pecker, Karen B. Avraham, Debra J. Gilbert, Kinneret Savitsky, Galit Rotman, Reli Harnik, Toshiyuki Fukao, Evelin Schröck, Shinji Hirotsune, Danilo A. Tagle, Francis S. Collins, Anthony Wynshaw-Boris, Thomas Ried, Neal G. Copeland, Nancy A. Jenkins, Yosef Shiloh, Yael Ziv

Research output: Contribution to journalArticlepeer-review

Abstract

Atm, the mouse homolog of the human ATM gene defective in ataxia- telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalGenomics
Volume35
Issue number1
DOIs
StatePublished - 1 Jul 1996

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