Identical HLA class II alleles predispose to drug-triggered and idiopathic pemphigus vulgaris

Y. Matzner, H. A. Erlich, C. Brautbar, A. Sanilevitch, M. Landau, S. Brenner, A. Friedmann

Research output: Contribution to journalArticlepeer-review

Abstract

In pemphigus vulgaris, a dermatological autoimmune disease, specific human leukocyte antigen (HLA) class II alleles, DR4 (DRB1*0402) and DRw14 (DRB1*1401, in linkage disequilibrium with DQB1*0503), are thought to be susceptibility genes involved in the onset of the disease. We studied the HLA class II alleles (DQA1, DQB1, DRB1 and DPB1) of 6 patients with pemphigus, in whom the disease was 'triggered' by drugs containing sulphydryl or another sulphur-containing group. All patients carried the DRB1*0402 susceptibility allele, and one patient also carried the second susceptibility allele, namely DQB1*0503 (in linkage with DRB1*1401). Bacterial, viral or environmental agents are suspected to trigger the onset of autoimmune diseases. Our study demonstrated the presence in patients with drug-triggered pemphigus vulgaris of the same HLA alleles thought to predispose to idiopathic pemphigus vulgaris. This finding strengthens the notion that these HLA alleles may be true disease susceptibility genes.

Original languageEnglish
Pages (from-to)12-14
Number of pages3
JournalActa Dermato-Venereologica
Volume75
Issue number1
StatePublished - 1995
Externally publishedYes

Keywords

  • Autoimmune disease
  • Drug-induced pemphigus

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