ICSI outcome in patients with transient azoospermia with initially motile or immotile sperm in the ejaculate

Joseph Tal*, G. Ziskind, Y. Paltieli, Z. Leibovitz, A. Fishman, G. Ohel, G. Paz, N. Lewit, I. Calderon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: In patients with transient azoospermia, few sperm may be found in the ejaculate. We investigated the outcome of ICSI in patients with transient azoospermia. Methods: Records of patients with transient azoospermia referred during a 42 month period were reviewed. If only immotile sperm were found, the sample was incubated with 30% human serum albumin (HSA) before motility re-assessment. If still immotile, mechanical assessment of sperm viability was utilized. Study groups were: (A) motile sperm; (B) motility achieved by HSA; (C) no motility, but viability assessed by a mechanical technique; and (D) control group with sperm counts from 1 to 5×106/ml. There were 57 couples (cycles) in the study group and 43 couples (cycles) in the control group. Results: Age, days of stimulation and endometrial thickness were comparable among groups. In 29.8% of the cycles, only immotile sperm were found. Fertilization and cleavage rates were higher in groups A and D than in groups B and C. Clinical pregnancy rate/cycle and live birth rate/cycle were not different among groups. No congenital malformations were found in newborns. Conclusions: Fertilization and cleavage rates were lower in patients with initially immotile sperm compared with those with initially motile sperm and oligoasthenoteratozoospermia patients. Clinical pregnancy and viable pregnancy rates were not statistically different among groups, although when only immotile sperm were present both clinical pregnancy and live birth rate were lower in comparison with cycles with motile sperm.

Original languageEnglish
Pages (from-to)2584-2589
Number of pages6
JournalHuman Reproduction
Issue number9
StatePublished - Sep 2005
Externally publishedYes


  • Azoospermia
  • ICSI
  • Immotile sperm motile sperm


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