Ibrutinib for the treatment of Bing-Neel syndrome: A multicenter study

Jorge J. Castillo*, Gilad Itchaki, Jonas Paludo, Marzia Varettoni, Christian Buske, Toby A. Eyre, Julio C. Chavez, Kenneth H. Shain, Samar Issa, M. Lia Palomba, Oren Pasvolsky, David Simpson, Dipti Talaulikar, Constantine S. Tam, Alessandra Tedeschi, Stephen M. Ansell, Lakshmi Nayak, Steven P. Treon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The treatment of patients with Bing-Neel syndrome (BNS) is not standardized. We included patients with Waldenström macroglobulinemia (WM) and a radiologic and/or cytologic diagnosis of BNS treated with ibrutinib monotherapy. Response assessment was based on criteria for BNS from the 8th International Workshop for WM. Survival from BNS diagnosis (BNS survival), survival from ibrutinib initiation to last follow-up or death (ibrutinib survival), and time fromibrutinib initiation to ibrutinib discontinuation for toxicity, progression, or death (event-free survival [EFS]) were estimated. Twenty-eight patients were included in our study. Themedian age atBNS diagnosis was 65 years. Ibrutinib was the first line of treatment for BNS in 39% of patients. Ibrutinib was administered orally at a dose of 560 and 420 mg once daily in 46% and 54% of patients, respectively; symptomatic and radiologic improvements were seen in 85%and 60% of patients within 3 months of therapy. At best response, 85% of patients had improvement or resolution of BNS symptoms, 83% had improvement or resolution of radiologic abnormalities, and 47% had cleared the disease in the cerebrospinal fluid. The 2-year EFS rate with ibrutinibwas 80%(95% confidence interval [CI], 58%-91%), the 2-year ibrutinib survival rate was 81%(95% CI, 49%-94%), and the 5-year BNS survival ratewas 86% (95% CI, 63%-95%). Ibrutinib therapy is effectiveinpatientswithBNSandshouldbeconsideredas atreatmentoptioninthese patients.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
Issue number4
StatePublished - 24 Jan 2019
Externally publishedYes


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