I-motif nanospheres: Unusual self-assembly of long cytosine strands

Dragoslav Zikich; Ke Liu; Lior Sagiv; Danny Porath; Alexander Kotlyar

doi:10.1002/smll.201002213

I-motif nanospheres: Unusual self-assembly of long cytosine strands

Dragoslav Zikich, Ke Liu, Lior Sagiv, Danny Porath^*, Alexander Kotlyar

^*Corresponding author for this work

Biochemistry Molecular Biology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The synthesis and characterization of novel DNA structures based on tetraplex cytosine (C) arrangements, known as i-motifs or i-tetraplexes, is reported. Atomic force microscopy (AFM) investigation shows that long C-strands in mild acidic conditions form compact spherically shaped nanostructures. The DNA nanospheres are characterized by a typical uniform shape and narrow height distribution. Electrostatic force microscopy (EFM) measurements performed on the i-motif spheres clearly show their electrical polarizability. Further investigations by scanning tunneling microscopy (STM) at ultrahigh vacuum reveals that the structures exhibit an average voltage gap of 1.9 eV, which is narrower than the voltage gap previously measured for poly(dG)-poly(dC) molecules in similar conditions.

Original language	English
Pages (from-to)	1029-1034
Number of pages	6
Journal	Small
Volume	7
Issue number	8
DOIs	https://doi.org/10.1002/smll.201002213
State	Published - 18 Apr 2011

Keywords

DNA
atomic force microscopy
i-motifs
nanostructures
self-assembly

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10.1002/smll.201002213

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abstract = "The synthesis and characterization of novel DNA structures based on tetraplex cytosine (C) arrangements, known as i-motifs or i-tetraplexes, is reported. Atomic force microscopy (AFM) investigation shows that long C-strands in mild acidic conditions form compact spherically shaped nanostructures. The DNA nanospheres are characterized by a typical uniform shape and narrow height distribution. Electrostatic force microscopy (EFM) measurements performed on the i-motif spheres clearly show their electrical polarizability. Further investigations by scanning tunneling microscopy (STM) at ultrahigh vacuum reveals that the structures exhibit an average voltage gap of 1.9 eV, which is narrower than the voltage gap previously measured for poly(dG)-poly(dC) molecules in similar conditions.",

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AU - Liu, Ke

AU - Sagiv, Lior

AU - Porath, Danny

AU - Kotlyar, Alexander

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I-motif nanospheres: Unusual self-assembly of long cytosine strands

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