TY - JOUR
T1 - Hypothyroidism and Dyshormonogenesis Induced by D-Penicillamine in Children with Wilson's Disease and Healthy Infants Born to a Mother with Wilson's Disease
AU - Hanukoglu, Aaron
AU - Curiel, Batya
AU - Berkowitz, Drora
AU - Levine, Arieh
AU - Sack, Joseph
AU - Lorberboym, Mordehai
PY - 2008/12
Y1 - 2008/12
N2 - Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.
AB - Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.
UR - http://www.scopus.com/inward/record.url?scp=56049095077&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2008.06.015
DO - 10.1016/j.jpeds.2008.06.015
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C2 - 19014823
AN - SCOPUS:56049095077
SN - 0022-3476
VL - 153
SP - 864-866.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -