Hypothyroidism and Dyshormonogenesis Induced by D-Penicillamine in Children with Wilson's Disease and Healthy Infants Born to a Mother with Wilson's Disease

Aaron Hanukoglu, Batya Curiel, Drora Berkowitz, Arieh Levine, Joseph Sack, Mordehai Lorberboym

Research output: Contribution to journalArticlepeer-review

Abstract

Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.

Original languageEnglish
Pages (from-to)864-866.e2
JournalJournal of Pediatrics
Volume153
Issue number6
DOIs
StatePublished - Dec 2008

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