TY - JOUR
T1 - Hypothesis
T2 - Familial Mediterranean fever - A genetic disorder of the lipocortin family?
AU - Shohat, M.
AU - Korenberg, J. R.
AU - Schwabe, A. D.
AU - Rotter, J. I.
PY - 1989
Y1 - 1989
N2 - Familial Mediterranean fever is an autosomal recessively inherited disorder of unknwon cause characterized by recurrent attacks of inflammation, involving mainly the peritoneum, pleura, synovia, and skin. Based on a phenotype analysis, we propose that its manifestations may be related to a genetic defect in one of the family of lipocortin proteins. Evidence is presented supporting an abnormality in the first step of prostaglandin/leukotriene synthesis.
AB - Familial Mediterranean fever is an autosomal recessively inherited disorder of unknwon cause characterized by recurrent attacks of inflammation, involving mainly the peritoneum, pleura, synovia, and skin. Based on a phenotype analysis, we propose that its manifestations may be related to a genetic defect in one of the family of lipocortin proteins. Evidence is presented supporting an abnormality in the first step of prostaglandin/leukotriene synthesis.
UR - http://www.scopus.com/inward/record.url?scp=0024419112&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320340205
DO - 10.1002/ajmg.1320340205
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C2 - 2530899
AN - SCOPUS:0024419112
SN - 0148-7299
VL - 34
SP - 163
EP - 167
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
IS - 2
ER -