Hypothalamic norepinephrine mediates limbic effects on adrenocortical secretion

Shaul Feldman; Nissim Conforti; Eldad Melamed

doi:10.1016/0361-9230(88)90197-9

Hypothalamic norepinephrine mediates limbic effects on adrenocortical secretion

Shaul Feldman^*, Nissim Conforti, Eldad Melamed

^*Corresponding author for this work

Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The purpose of this study was to elucidate the role of norepinephrine (NE) in the mediation of adrenocortical responses following limbic stimuli. The effects of stimulation of the dorsal and ventral hippocampus and the midbrain reticular formation on the plasma corticosterone (CS) levels was studied in rats with vehicle or 6-hydroxydopamine (6-OHDA) injected bilaterally into the paraventricular nucleus of the hypothalamus (PVN). The injection of 6-OHDA caused a very significant reduction in the concentration of PVN NE and blocked the rise in plasma CS following the stimulation of the above three limbic structures. The basal CS level and the response to ether stress were not affected. The present study supports previous observations on the stimulatory role of NE on CS secretion and that the modulatory effects of extrahypothalamic limbic structures on the adrenocortical activity depend on the presence of NE in the PVN.

Original language	English
Pages (from-to)	587-590
Number of pages	4
Journal	Brain Research Bulletin
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0361-9230(88)90197-9
State	Published - Oct 1988
Externally published	Yes

Keywords

6-Hydroxydopamine
Corticosterone secretion
Hippocampus
Norepinephrine
Paraventricular nucleus
Reticular formation

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10.1016/0361-9230(88)90197-9

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title = "Hypothalamic norepinephrine mediates limbic effects on adrenocortical secretion",

abstract = "The purpose of this study was to elucidate the role of norepinephrine (NE) in the mediation of adrenocortical responses following limbic stimuli. The effects of stimulation of the dorsal and ventral hippocampus and the midbrain reticular formation on the plasma corticosterone (CS) levels was studied in rats with vehicle or 6-hydroxydopamine (6-OHDA) injected bilaterally into the paraventricular nucleus of the hypothalamus (PVN). The injection of 6-OHDA caused a very significant reduction in the concentration of PVN NE and blocked the rise in plasma CS following the stimulation of the above three limbic structures. The basal CS level and the response to ether stress were not affected. The present study supports previous observations on the stimulatory role of NE on CS secretion and that the modulatory effects of extrahypothalamic limbic structures on the adrenocortical activity depend on the presence of NE in the PVN.",

keywords = "6-Hydroxydopamine, Corticosterone secretion, Hippocampus, Norepinephrine, Paraventricular nucleus, Reticular formation",

author = "Shaul Feldman and Nissim Conforti and Eldad Melamed",

year = "1988",

month = oct,

doi = "10.1016/0361-9230(88)90197-9",

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AU - Feldman, Shaul

AU - Conforti, Nissim

AU - Melamed, Eldad

PY - 1988/10

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N2 - The purpose of this study was to elucidate the role of norepinephrine (NE) in the mediation of adrenocortical responses following limbic stimuli. The effects of stimulation of the dorsal and ventral hippocampus and the midbrain reticular formation on the plasma corticosterone (CS) levels was studied in rats with vehicle or 6-hydroxydopamine (6-OHDA) injected bilaterally into the paraventricular nucleus of the hypothalamus (PVN). The injection of 6-OHDA caused a very significant reduction in the concentration of PVN NE and blocked the rise in plasma CS following the stimulation of the above three limbic structures. The basal CS level and the response to ether stress were not affected. The present study supports previous observations on the stimulatory role of NE on CS secretion and that the modulatory effects of extrahypothalamic limbic structures on the adrenocortical activity depend on the presence of NE in the PVN.

AB - The purpose of this study was to elucidate the role of norepinephrine (NE) in the mediation of adrenocortical responses following limbic stimuli. The effects of stimulation of the dorsal and ventral hippocampus and the midbrain reticular formation on the plasma corticosterone (CS) levels was studied in rats with vehicle or 6-hydroxydopamine (6-OHDA) injected bilaterally into the paraventricular nucleus of the hypothalamus (PVN). The injection of 6-OHDA caused a very significant reduction in the concentration of PVN NE and blocked the rise in plasma CS following the stimulation of the above three limbic structures. The basal CS level and the response to ether stress were not affected. The present study supports previous observations on the stimulatory role of NE on CS secretion and that the modulatory effects of extrahypothalamic limbic structures on the adrenocortical activity depend on the presence of NE in the PVN.

KW - 6-Hydroxydopamine

KW - Corticosterone secretion

KW - Hippocampus

KW - Norepinephrine

KW - Paraventricular nucleus

KW - Reticular formation

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Hypothalamic norepinephrine mediates limbic effects on adrenocortical secretion

Abstract

Keywords

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